منابع مشابه
Iron: an emerging factor in colorectal carcinogenesis.
The carcinogenic potential of iron in colorectal cancer (CRC) is not fully understood. Iron is able to undergo reduction and oxidation, making it important in many physiological processes. This inherent redox property of iron, however, also renders it toxic when it is present in excess. Iron-mediated generation of reactive oxygen species via the Fenton reaction, if uncontrolled, may lead to cel...
متن کاملpetrology and geochemistry of khar-bash (western shahrood) and its relation ship to iron mineralization
منطقه مورد مطالعه در 23 کیلومتری جنوب غرب شهرستاشاهرود قرار دارد که در نقشه 100000/1 شاهرود قرار گرفته است.ناحیه مورد مطالعه در تقسیمات ساختاری ایران بخشی از زون البرز شرقی است . در طی سنوزوئیک این زون به شدت تحت تأثیر فازهای کوهزایی آلپی قرار گرفته و فعالیت های آتشفشانی انوسن در قسمت های غربی آن دیده می شود . از نظر ترکیب سنگ شناسی منطقه مورد مطالعه متنوع و بیشتر شامل سنگ های رسوبی مانند : آ...
15 صفحه اولInhibition of azo dye carcinogenesis by thorotrast and iron oxide.
Evidence that the reticulo-endothelial system (R.E.S.) may be involved in the carcinogenic proc ess has been presented by Stern and Willheim (22) and by Jaffe (11). This system has also been im plicated in the metabolism of certain fat-soluble materials such as Vitamin A (3,10,17) and choles terol (3, 23) and the water-soluble vitamin, riboflavin (2, 9, 10). Since riboflavin is a factor in the ...
متن کاملFormation of acrolein-derived 2'-deoxyadenosine adduct in an iron-induced carcinogenesis model.
Acrolein is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidase-catalyzed amino acid oxidation. It shows facile reactivity toward DNA to form an exocyclic DNA adduct. To verify the formation of acrolein-derived DNA adduct under oxidative stress in vivo, we raised a novel ...
متن کاملRole of iron in carcinogenesis: cancer as a ferrotoxic disease.
Iron is abundant universally. During the evolutionary processes, humans have selected iron as a carrier of oxygen inside the body. However, iron works as a double-edged sword, and its excess is a risk for cancer, presumably via generation of reactive oxygen species. Thus far, pathological conditions such as hemochromatosis, chronic viral hepatitis B and C, exposure to asbestos fibers, as well a...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2010
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.99.1277